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Isolation of functional autologous collagen-II specific IL-10 producing Tr1 cell clones from rheumatoid arthritis blood.

International immunopharmacology - 1 Aug 2011

Brun Valérie, Neveu Virginie, Pers Yves Marie, Fabre Sylvie, Quatannens Brigitte, Bastian Hervé, Clerget-Chossat Nathalie, Jorgensen Christian, Foussat Arnaud

Abstract excerpt

IL-10 producing regulatory type 1 (Tr1) cells represents a subpopulation of CD4+ regulatory cells able to prevent in vitro bystander T-cell proliferation and to inhibit a wide range of inflammatory diseases in mice. Our aim was to evaluate the frequency and function of joint specific Tr1 cells in the peripheral blood of severe Rheumatoid Arthritis (RA) patients. The collagen II protein was chosen to isolate Tr1...

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Identifiers

PMID: 21406270
DOI: 10.1016/j.intimp.2011.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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