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Article

Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia

31 Aug 2007

Abstract excerpt

Regulatory T (Tr) cells have the potential to treat immune-mediated disease, but cloning such cells for study from patients with autoimmune disease has proven difficult. Here, we describe autoantigen-specific, interleukin-10 (IL-10)-secreting Tr cell clones recovered ex vivo from a patient with autoimmune hemolytic anemia (AIHA) and characterize their phenotype, origin, and regulatory function. These IL-10+ Tr...

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Identifiers

PMID: 17761830
DOI: 10.1182/blood-2007-07-101345

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