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Article

Rapid Isolation of Functional ex vivo Human Skin Tissue-Resident Memory T Lymphocytes.

Frontiers in immunology - 1 Jan 2021

Du Weijie, Lenz Daniel, Köhler Ralf, Zhang Erping, Cendon Carla, Li Jinchan, Massoud Mona, Wachtlin Joachim, Bodo Juliane, Hauser Anja E, Radbruch Andreas, Dong Jun

Abstract excerpt

Studies in animal models have shown that skin tissue-resident memory T (TRM) cells provide enhanced and immediate effector function at the site of infection. However, analyses of skin TRM cells in humans have been hindered by the lack of an optimized isolation protocol. Here, we present a combinatorial strategy-the 6-h collagenase IV digestion and gentle tissue dissociation - for rapid and efficient isolation of...

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Identifiers

PMID: 33828548
DOI: 10.3389/fimmu.2021.624013
PMCID: PMC8019735

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