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Article

Escherichia coli σ⁷⁰ senses sequence and conformation of the promoter spacer region.

Nucleic acids research - 1 Jul 2011

Singh Shivani S, Typas Athanasios, Hengge Regine, Grainger David C

Abstract excerpt

In bacteria, promoter identification by RNA polymerase is mediated by a dissociable σ factor. The housekeeping σ(70) factor of Escherichia coli recognizes two well characterized DNA sequence elements, known as the '-10' and '-35' hexamers. These elements are separated by 'spacer' DNA, the sequence of which is generally considered unimportant. Here, we use a combination of bioinformatics, genetics and biochemistry...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21398630
DOI: 10.1093/nar/gkr080
PMCID: PMC3130263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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