Article
Two major inositol transporters and their role in cryptococcal virulence.
Eukaryotic cell - 1 May 2011
Wang Yina, Liu Tong-bao, Delmas Guillaume, Park Steven, Perlin David, Xue Chaoyang
Abstract excerpt
Cryptococcus neoformans is an AIDS-associated human fungal pathogen and the most common cause of fungal meningitis, with a mortality rate over 40% in AIDS patients. Significant advances have been achieved in understanding its disease mechanisms. Yet the underlying mechanism of a high frequency of cryptococcal meningitis remains unclear. The existence of high inositol concentrations in brain and our earlier...
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