Article
Candida albicans uses multiple mechanisms to acquire the essential metabolite inositol during infection.
Infection and immunity - 1 Jun 2008
Chen Ying-Lien, Kauffman Sarah, Reynolds Todd B
Abstract excerpt
Candida albicans is an important cause of life-threatening systemic bloodstream infections in immunocompromised patients. In order to cause infections, C. albicans must be able to synthesize the essential metabolite inositol or acquire it from the host. Based on the similarity of C. albicans to Saccharomyces cerevisiae, it was predicted that C. albicans may generate inositol de novo, import it from the...
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