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Article

Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans.

Nature communications - 2 Dec 2024

Jackson Katrina M, Kono Thomas J Y, Betancourt Jovany J, Wang Yina, Kabbale Kisakye D, Ding Minna, Kezh Perry, Ha Grace, Yoder J Marina, Fulton Sophie R, Mukaremera Liliane, Tiffin Peter, Gusa Asiya, Meya David B, Billmyre R Blake, Xue Chaoyang, Nielsen Kirsten

Abstract excerpt

Studies across various pathogens highlight the importance of pathogen genetic differences in disease manifestation. In the human fungal pathogen Cryptococcus neoformans, sequence type (ST) associates with patient outcome. We performed a meta-analysis of four genomic studies and identified overlapping gene regions associated with virulence, suggesting the importance of these gene regions in cryptococcal disease in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39622806
DOI: 10.1038/s41467-024-54729-6
PMCID: PMC11612297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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