Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans.

doi:10.1038/s41467-024-54729-6

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Article

Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans.

Nature communications - 2 Dec 2024

Jackson Katrina M, Kono Thomas J Y, Betancourt Jovany J, Wang Yina, Kabbale Kisakye D, Ding Minna, Kezh Perry, Ha Grace, Yoder J Marina, Fulton Sophie R, Mukaremera Liliane, Tiffin Peter, Gusa Asiya, Meya David B, Billmyre R Blake, Xue Chaoyang, Nielsen Kirsten

Abstract excerpt

Studies across various pathogens highlight the importance of pathogen genetic differences in disease manifestation. In the human fungal pathogen Cryptococcus neoformans, sequence type (ST) associates with patient outcome. We performed a meta-analysis of four genomic studies and identified overlap...

Topics

Animals
Humans
Mice
Cryptococcosis
Cryptococcus neoformans
Disease Models, Animal
Fungal Proteins
Gene Expression Regulation, Fungal
Genome-Wide Association Study
Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Species Specificity

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 39622806
DOI: 10.1038/s41467-024-54729-6
PMCID: PMC11612297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-39622806-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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