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Article

Downregulation of SOK1 promotes the migration of MCF-7 cells

11 Mar 2011

Abstract excerpt

SOK1 is a member of the germinal center kinase (GCK-III) subfamily but little is known about it, particularly with respect to its role in signal transduction pathways relative to tumor metastasis. By stably transfecting SOK1 siRNA into the MCF-7 breast cancer cell line we found that SOK1 promotes the migration of MCF-7 cells, as determined using wound-healing and Boyden chamber assays. However, cell proliferation...

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PMID: 21396913
DOI: 10.1016/j.bbrc.2011.03.031

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