Article

Nucleocytoplasmic distribution of S6K1 depends on the density and motility of MCF-7 cells in vitro

2018-12-17

Abstract excerpt

<h4>Background: </h4> The ribosomal protein S6 kinase 1 (S6K1) is one of the main components of the mTOR/S6K signal transduction pathway, which controls cellular metabolism, autophagy, growth, and proliferation. Overexpression of S6K1 was detected in tumors of different origin including breast cancer, and correlated with the worse disease outcome. In addition, significant accumulation of S6K1 was found in the nucl...

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Literature Corpus work: d8300c18-4d77-58d0-96bc-9a68d43ca99a
DOI: 10.12688/f1000research.15447.2

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