Article

Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway

2023-01-19

Abstract excerpt

Constitutively active mutations in the Gα i2 and Gα oA subunits of heterotrimeric G proteins have been identified in several human cancers including breast cancer, but their functional significance in tumorigenesis and metastasis has not been well characterized. In this study, we show that expression of the constitutively active Gα oA R243H and Gα i2 R179C mutants alone was insufficient to induce mammary tumor...

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Literature Corpus work: c0a275ee-87f1-506f-822b-457d99cf0c11
DOI: 10.1101/2023.01.16.524334

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