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Article

Role of the CD47-SHPS-1 system in regulation of cell migration.

The EMBO journal - 2 Jun 2003

Motegi Sei-Ichiro, Okazawa Hideki, Ohnishi Hiroshi, Sato Ryuji, Kaneko Yoriaki, Kobayashi Hisae, Tomizawa Kyoko, Ito Tomokazu, Honma Nakayuki, Bühring Hans-Jörg, Ishikawa Osamu, Matozaki Takashi

Abstract excerpt

SHPS-1 is a transmembrane protein whose extracellular region interacts with CD47 and whose cytoplasmic region undergoes tyrosine phosphorylation and there by binds the protein tyrosine phosphatase SHP-2. Formation of this complex is implicated in regulation of cell migration by an unknown mechanism. A CD47-Fc fusion protein or antibodies to SHPS-1 inhibited migration of human melanoma cells or of CHO cells...

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Identifiers

PMID: 12773380
DOI: 10.1093/emboj/cdg278
PMCID: PMC156773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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