Article
Differential detection of M184V/I between plasma historical HIV genotypes and HIV proviral DNA from PBMCs.
The Journal of antimicrobial chemotherapy - 1 Aug 2020
Margot Nicolas, Ram Renee, McNicholl Ian, Haubrich Richard, Callebaut Christian
Abstract excerpt
BACKGROUND: The M184V/I reverse transcriptase mutation, which confers major resistance to lamivudine and emtricitabine, is still quite frequent in people living with HIV. The underlying presence of the M184V/I mutation may undermine virological outcomes of ART, particularly in the context of proposed treatment with two-drug combinations that include drugs affected by M184V, such as lamivudine. In suppressed...
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