Genotypic resistance test in proviral DNA can identify resistance mutations never detected in historical genotypic test in patients with low level or undetectable HIV-RNA.

doi:10.1016/j.jcv.2016.07.007

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Article

Genotypic resistance test in proviral DNA can identify resistance mutations never detected in historical genotypic test in patients with low level or undetectable HIV-RNA.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Sept 2016

Zaccarelli Mauro, Santoro Maria Mercedes, Armenia Daniele, Borghi Vanni, Gennari William, Gori Caterina, Forbici Federica, Bertoli Ada, Fabeni Lavinia, Giannetti Alberto, Cicalini Stefania, Bellagamba Rita, Andreoni Massimo, Mastroianni Claudio Maria, Mussini Cristina, Ceccherini-Silberstein Francesca, Perno Carlo Federico, Antinori Andrea

Abstract excerpt

BACKGROUND: Beyond the detection of resistant HIV strains found in plasma samples, archival HIV-DNA in peripheral blood mononuclear cells (PBMCs) might represent a reservoir of additional resistance. OBJECTIVE: To characterize the HIV-1 resistance in PBMCs from patients with suppressed or low-level viremia (50-1000 copies/mL) and evaluate its added value compared to the resistance detected in previous plasma...

Topics

Adult
DNA, Viral
Drug Resistance, Viral
Female
Genotyping Techniques
HIV Infections
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Male

Microbial Sensitivity Tests

Middle Aged

Mutation

Proviruses

RNA, Viral

Retrospective Studies

Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 27472519
DOI: 10.1016/j.jcv.2016.07.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27472519-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genotypic resistance test in proviral DNA can identify resistance mutations never detected in historical genotypic test in patients with low level or undetectable HIV-RNA.PMID 27472519Read ↗

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