Article
Proviral DNA as a Target for HIV-1 Resistance Analysis.
Intervirology - 1 Jan 2015
Lübke Nadine, Di Cristanziano Veronica, Sierra Saleta, Knops Elena, Schülter Eugen, Jensen Björn, Oette Mark, Lengauer Thomas, Kaiser Rolf
Abstract excerpt
BACKGROUND: Resistance analysis from viral RNA is restricted to detectable viral load. Therefore, analysis from proviral DNA could help in cases with low-level or suppressed viremia. METHODS: Viral plasma RNA and the corresponding cellular proviral DNA of 78 EDTA samples from 48 therapy-naïve (TN) and 30 therapy-experienced (TE) HIV-1-infected patients were isolated and analyzed for their resistance profiles in...
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