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Article

High levels of protein C are determined by PROCR haplotype 3.

Journal of thrombosis and haemostasis : JTH - 1 May 2011

Pintao M C, Roshani S, de Visser M C H, Tieken C, Tanck M W T, Wichers I M, Meijers J C M, Rosendaal F R, Middeldorp S, Reitsma P H

Abstract excerpt

BACKGROUND: Genetic determinants of plasma levels of protein C (PC) are poorly understood. Recently, we identified a locus on chromosome 20 determining high PC levels in a large Dutch pedigree with unexplained thrombophilia. Candidate genes in the LOD-1 support interval included FOXA2, THBD and PROCR. OBJECTIVES: To examine these candidate genes and their influence on plasma levels of PC. PATIENTS/METHODS: Exons,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21392254
DOI: 10.1111/j.1538-7836.2011.04256.x

Genes

PROCR
EDEM2
FOXA2
THBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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