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Article

Familial thrombotic risk based on the genetic background of Protein C Deficiency in a Portuguese Study.

European journal of haematology - 1 Oct 2015

Fidalgo Teresa, Martinho Patrícia, Salvado Ramon, Manco Licínio, Oliveira Ana C, Pinto Catarina S, Gonçalves Elsa, Marques Dalila, Sevivas Teresa, Martins Natália, Ribeiro Maria Letícia

Abstract excerpt

INTRODUCTION: Inherited protein C (PC) deficiency is a well-known risk factor for venous thrombosis (VT). Plasma PC levels are reliable in moderate to severe deficiencies; however, in mildly deficient individuals, the levels may overlap with those considered normal. Genetic studies of PROC, which encodes PC, could help identify carriers; genome-wide association studies (GWAS) have shown that approximately 50% of...

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Source

Identifiers

PMID: 25533856
DOI: 10.1111/ejh.12488

Genes

PROC
PROCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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