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Article

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

9 Mar 2022

Abstract excerpt

Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR-p.Ser219Gly as the likely causal...

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PMID: 35264566
DOI: 10.1038/s41467-022-28729-3

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