Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2013

Wu Cynthia, Dwivedi Dhruva J, Pepler Laura, Lysov Zakhar, Waye John, Julian Jim, Desch Karl, Ginsburg David, Weitz Jeffrey I, Kearon Clive, Liaw Patricia C

Abstract excerpt

OBJECTIVE: The interaction of protein C (PC) with the endothelial PC receptor (EPCR) enhances activated PC generation. We performed targeted gene sequencing of the PC gene (PROC) and EPCR genes (PROCR) in patients with unprovoked venous thromboembolism (VTE) to determine whether mutations that impair PC-EPCR interactions are associated with an increased risk of VTE. APPROACH AND RESULTS: We sequenced exon 3 of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haplotypes

Share to HEK293 Cells

Share to Protein C

Share to Receptors, Cell Surface

Share to Risk Factors

Share to Venous Thromboembolism

Source

Open in PubMed Open full text

Identifiers

PMID: 24051141
DOI: 10.1161/ATVBAHA.113.302137
PMCID: PMC4115806

Genes

PROC
PROCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism.PMID 24051141Read ↗

Thrombotic Risk Determined by Protein C Receptor (PROCR) Variants among Middle-Aged and Older Adults: A Population-Based Cohort StudySemantic proximity Read ↗

Analysis of the Phenotype and Gene Mutations of Two Families With Combined Mutations of Anticoagulant Protein Genes.Semantic proximity Read ↗

Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants.Semantic proximity Read ↗

Inherited abnormalities in the protein C activation pathway.Semantic proximity Read ↗

Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis.Semantic proximity Read ↗

Polymorphisms in the endothelial protein C receptor gene and thrombophilia.Semantic proximity Read ↗

Assessment of a next generation sequencing gene panel strategy in 133 patients with negative thrombophilia screening.Semantic proximity Read ↗

Bioinformatic analysis of rare endothelial protein C receptor missense variants associated with coagulation and thrombophilia risk.Semantic proximity Read ↗

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis.Semantic proximity Read ↗

Functional analysis of two haplotypes of the human endothelial protein C receptor gene.Semantic proximity Read ↗

The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.Semantic proximity Read ↗

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.