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Article

aro mutations in Salmonella enterica cause defects in cell wall and outer membrane integrity.

Journal of bacteriology - 1 May 2008

Sebkova Alena, Karasova Daniela, Crhanova Magdalena, Budinska Eva, Rychlik Ivan

Abstract excerpt

In this study we characterized aro mutants of Salmonella enterica serovars Enteritidis and Typhimurium, which are frequently used as live oral vaccines. We found that the aroA, aroD, and aroC mutants were sensitive to blood serum, albumen, EDTA, and ovotransferrin, and this defect could be complemented by an appropriate aro gene cloned in a plasmid. Subsequent microarray analysis of gene expression in the aroD...

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Identifiers

PMID: 18310348
DOI: 10.1128/JB.00053-08
PMCID: PMC2347392

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