Article
Oral vaccination of calves against experimental salmonellosis using a double aro mutant of Salmonella typhimurium.
Vaccine - 1 Jan 1991
Jones P W, Dougan G, Hayward C, Mackensie N, Collins P, Chatfield S N
Abstract excerpt
An attenuated derivative of the fully calf virulent Salmonella typhimurium strain ST4/74 was constructed by introducing stable mutations into genes aroA and aroD rendering the strain dependent for growth on aromatic compounds. The strain (BRD562) was used to vaccinate orally ten Friesian calves 7 days after birth with approximately 10(10) live organisms. The only effects of vaccination in the calves was a...
Topics
- Administration, Oral
- Animals
- Animals, Newborn
- Antibodies, Bacterial
- Bacterial Vaccines
- Cattle
- Cattle Diseases
- Mutation
- Salmonella Infections, Animal
- Salmonella typhimurium
- Vaccines, Attenuated