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Syntaxin binding mechanism and disease-causing mutations in Munc18-2

5 Nov 2013

Abstract excerpt

Mutations in either syntaxin 11 (Stx11) or Munc18-2 abolish cytotoxic T lymphocytes (CTL) and natural killer cell (NK) cytotoxicity, and give rise to familial hemophagocytic lymphohistiocytosis (FHL4 or FHL5, respectively). Although Munc18-2 is known to interact with Stx11, little is known about the molecular mechanisms governing the specificity of this interaction or how in vitro IL-2 activation leads to...

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PMID: 24194549
DOI: 10.1073/pnas.1313474110

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Syntaxin binding mechanism and disease-causing mutations in Munc18-2PMID 24194549Read ↗

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