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Article

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.

The EMBO journal - 17 Jan 2018

Meijer Marieke, Dörr Bernhard, Lammertse Hanna Ca, Blithikioti Chrysanthi, van Weering Jan Rt, Toonen Ruud Fg, Söllner Thomas H, Verhage Matthijs

Abstract excerpt

Tyrosine kinases are important regulators of synaptic strength. Here, we describe a key component of the synaptic vesicle release machinery, Munc18-1, as a phosphorylation target for neuronal Src family kinases (SFKs). Phosphomimetic Y473D mutation of a SFK phosphorylation site previously identified by brain phospho-proteomics abolished the stimulatory effect of Munc18-1 on SNARE complex formation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29150433
DOI: 10.15252/embj.201796484
PMCID: PMC5770875

Genes

VAMP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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