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Article

Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Jun 2016

Munch Anders S, Kedar Girish H, van Weering Jan R T, Vazquez-Sanchez Sonia, He Enqi, André Timon, Braun Thimo, Söllner Thomas H, Verhage Matthijs, Sørensen Jakob B

Abstract excerpt

UNLABELLED: Munc18-1 is essential for vesicle fusion and participates in the docking of large dense-core vesicles to the plasma membrane. Recent structural data suggest that conformational changes in the 12th helix of the Munc18-1 domain 3a within the Munc18-1:syntaxin complex result in an additional interaction with synaptobrevin-2/VAMP2 (vesicle-associated membrane protein 2), leading to SNARE complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27358447
DOI: 10.1523/JNEUROSCI.0007-16.2016
PMCID: PMC6604893

Genes

VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.PMID 27358447Read ↗

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