Article
KRAS and BRAF mutations in Nigerian colorectal cancers.
West African journal of medicine - 1 Jan 2000
Abdulkareem F B, Sanni L A, Richman S D, Chambers P, Hemmings G, Grabsch H, Quirke P, Elesha S O, Banjo A F, Atoyebi O A, Adesanya A A, Onyekwere C A, Ojukwu J, Anomneze E E, Rotimi O
Abstract excerpt
PURPOSE: Activation of the KRAS oncogene is implicated in colorectal carcinogenesis and mutations have been reported in 30-50% of cases. BRAF mutation, though less common, is also reported and importantly associated with shorter progression-free interval. This study aims to determine the KRAS and BRAF mutation statuses of Nigerian colorectal cancers (CRC). METHODS: Mutation analysis was carried out on archival...
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