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Article

USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.

Human molecular genetics - 1 Jun 2011

Guervilly Jean-Hugues, Renaud Emilie, Takata Minoru, Rosselli Filippo

Abstract excerpt

The maintenance of genetic stability depends on the fine-tuned initiation and termination of pathways involved in cell cycle checkpoints and DNA repair. Here, we describe a new pathway that regulates checkpoint kinase 1 (CHK1) activity, a key element controlling both checkpoints and DNA repair. We show that the ubiquitin-specific peptidase 1 (USP1) deubiquitinase participates in the maintenance of both total and...

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Share to Checkpoint Kinase 1
Share to Endopeptidases
Share to Fanconi Anemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Proliferating Cell Nuclear Antigen

Share to Protein Kinases

Share to RNA, Small Interfering

Share to Ubiquitin-Specific Proteases

Source

Open in PubMed Open full text

Identifiers

PMID: 21389083
DOI: 10.1093/hmg/ddr103
PMCID: PMC3090195

Genes

USP1
FANCD2
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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