Article
Analysis of telomere dynamics in peripheral blood cells from patients with Lynch syndrome.
Cancer - 15 Sept 2011
Bozzao Cristina, Lastella Patrizia, Ponz de Leon Maurizio, Pedroni Monica, Di Gregorio Carmela, D'Ovidio Francesco D, Resta Nicoletta, Prete Fernando, Guanti Ginevra, Stella Alessandro
Abstract excerpt
BACKGROUND: In patients with Lynch syndrome, germline mutations in DNA mismatch repair (MMR) genes cause a high risk of developing a broad spectrum of cancers. To date, the management of patients with Lynch syndrome has represented a major challenge because of large variations in age at cancer onset. Several factors, including genetic anticipation, have been proposed to explain this phenotypic heterogeneity, but...
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