Article

DNA mismatch repair deficiency and telomere dynamics

2019-01-01

Abstract excerpt

DNA mismatch repair (MMR) deficiency is the hallmark of Lynch syndrome (LS), an autosomal inherited predisposition for an early onset of colorectal cancer (CRC) characterized by the presence of high levels of microsatellite instability. CRC cell lines carrying a MMR gene mutation show higher mutation rates than MMR-proficient cells not only at microsatellites but also at telomeres. Here, the MMR protein MSH2 was d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cd2c722-a64a-5d68-a48e-f9d374b4cc21
DOI: 10.25392/leicester.data.11337017.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA mismatch repair deficiency and telomere dynamicsDOI 10.25392/leicester.data.11337017.v1Read

Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells.Semantic proximity Read

Mismatch Repair Pathway, Genome Stability and CancerSemantic proximity Read

Oxidative Stress Accelerates Repeat Instability and Base Substitutions, Promoting Gastrointestinal Driver Mutations under MSH2 DeficiencySemantic proximity Read

Structure and function of the components of the human DNA mismatch repair systemSemantic proximity Read

DNA mismatch repair, microsatellite instability and cancer.Semantic proximity Read

Genetic instability influences drug response in cancer cells.Semantic proximity Read

Analysis of telomere dynamics in peripheral blood cells from patients with Lynch syndrome.Semantic proximity Read

Looking Beyond the Cytogenetics in Haematological Malignancies- Decoding the Role of Tandem Repeats in DNA Repair GenesSemantic proximity Read

Microsatellite instability and DNA mismatch repair in human cancerSemantic proximity Read

Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesSemantic proximity Read

MSH2 deficiency abolishes the anticancer and pro‐aging activity of short telomeresSemantic proximity Read

The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancerSemantic proximity Read