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Article

Association of Mismatch Repair Mutation With Age at Cancer Onset in Lynch Syndrome: Implications for Stratified Surveillance Strategies.

JAMA oncology - 1 Dec 2017

Ryan Neil A J, Morris Julie, Green Kate, Lalloo Fiona, Woodward Emma R, Hill James, Crosbie Emma J, Evans D Gareth

Abstract excerpt

Importance: Lynch syndrome is caused by dominantly inherited germline mutations that predispose individuals to colorectal, endometrial, ovarian, and other cancers through inactivation of the cellular mismatch repair system. Lynch syndrome–associated cancers are amenable to surveillance strategies that may improve survival. The age at which surveillance should start is disputed. Objective: To determine whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28772289
DOI: 10.1001/jamaoncol.2017.0619
PMCID: PMC5824283

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

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