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Article

Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome.

Cancer research - 15 Feb 2007

Tabori Uri, Nanda Sonia, Druker Harriet, Lees Jodi, Malkin David

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome frequently associated with germ line TP53 mutations. Unpredictable and disparate age of cancer onset is a major challenge in the management of LFS. Genetic modifiers, including the MDM2-SNP309 polymorphism, and genetic anticipation have been suggested as plausible explanations for young age of tumor onset, but the molecular mechanisms for these...

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Source

Identifiers

PMID: 17308077
DOI: 10.1158/0008-5472.CAN-06-3682

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome.PMID 17308077Read ↗

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