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Article

MSH2 deficiency abolishes the anticancer and pro‐aging activity of short telomeres

5 Nov 2008

Abstract excerpt

Mutations in the mismatch repair (MMR) pathway occur in human colorectal cancers with microsatellite instability. Mounting evidence suggests that cell-cycle arrest in response to a number of cellular stresses, including telomere shortening, is a potent anticancer barrier. The telomerase-deficient mouse model illustrates the anticancer effect of cell-cycle arrest provoked by short telomeres. Here, we describe a...

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PMID: 18986375
DOI: 10.1111/j.1474-9726.2008.00441.x

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