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Article

Genetic anticipation is associated with telomere shortening in hereditary breast cancer.

PLoS genetics - 1 Jul 2011

Martinez-Delgado Beatriz, Yanowsky Kira, Inglada-Perez Lucia, Domingo Samuel, Urioste Miguel, Osorio Ana, Benitez Javier

Abstract excerpt

There is increasing evidence suggesting that short telomeres and subsequent genomic instability contribute to malignant transformation. Telomere shortening has been described as a mechanism to explain genetic anticipation in dyskeratosis congenita and Li-Fraumeni syndrome. Since genetic anticipation has been observed in familial breast cancer, we aimed to study telomere length in familial breast cancer patients...

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Source

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Identifiers

PMID: 21829373
DOI: 10.1371/journal.pgen.1002182
PMCID: PMC3145621

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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