Apolipoprotein E isoform-dependent microglia migration.

doi:10.1096/fj.10-176891

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Article

Apolipoprotein E isoform-dependent microglia migration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2011

Cudaback Eiron, Li Xianwu, Montine Kathleen S, Montine Thomas J, Keene C Dirk

Abstract excerpt

Complement component C5a and ATP are potent effectors of microglial movement and are increased in diverse neurodegenerative diseases and at sites of injury. Apolipoprotein E (apoE) influences microglial function, and different human apoE isoforms confer variable risk for development of neurodegenerative disorders, especially Alzheimer's disease. The purpose of this investigation was to test the hypothesis that...

Topics

Animals
Apolipoproteins E
Cell Movement
Cells, Cultured
Chemotaxis
Gene Expression Regulation
Genotype
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout
Microglia
Protein Isoforms

Source

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Identifiers

PMID: 21385991
DOI: 10.1096/fj.10-176891
PMCID: PMC3101033

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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