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Article

Affinity and specificity of protein U1A-RNA complex formation based on an additive component free energy model.

Journal of molecular biology - 31 Aug 2007

Kormos Bethany L, Benitex Yulia, Baranger Anne M, Beveridge David L

Abstract excerpt

An MM-GBSA computational protocol was used to investigate wild-type U1A-RNA and F56 U1A mutant experimental binding free energies. The trend in mutant binding free energies compared to wild-type is well-reproduced. Following application of a linear-response-like equation to scale the various energy components, the binding free energies agree quantitatively with observed experimental values. Conformational...

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Identifiers

PMID: 17603075
DOI: 10.1016/j.jmb.2007.06.003
PMCID: PMC2034351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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