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Article

Design of an adenosine analogue that selectively improves the affinity of a mutant U1A protein for RNA.

Journal of the American Chemical Society - 5 Mar 2003

Zhao Ying, Baranger Anne M

Abstract excerpt

The RNA recognition motif (RRM), one of the most common RNA binding domains, contains three highly conserved aromatic amino acids that participate in stacking interactions with RNA bases. We have investigated the contribution of these highly conserved aromatic amino acids to the affinity of the complex formed between the N-terminal RRM of the U1A protein and stem loop 2 of U1 snRNA. Previously, we found that...

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Share to Adenosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribonucleoprotein, U1 Small Nuclear

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Source

Identifiers

PMID: 12603136
DOI: 10.1021/ja021267w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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