Article
CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Cardiovascular research - 1 Aug 2017
Shu Ya-Nan, Dong Li-Hua, Li Han, Pei Qian-Qian, Miao Sui-Bing, Zhang Fan, Zhang Dan-Dan, Chen Rong, Yin Ya-Juan, Lin Yan-Ling, Xue Zhen-Ying, Lv Pin, Xie Xiao-Li, Zhao Li-Li, Nie Xi, Chen Peng, Han Mei
Abstract excerpt
AIMS: Sirtuin 1 (SIRT1) inhibits nuclear factor kappa B (NF-κB) activity in response to the inflammatory cytokine tumour necrosis factor alpha (TNF-α). Smooth muscle (SM) 22α is a phosphorylation-regulated suppressor of IKK-IκBα-NF-κB signalling cascades in vascular smooth muscle cells (VSMCs). Sm22α knockout results in increased expression of pro-inflammatory genes in the aortas which are controlled by NF-κB....
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