Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2011

Fu Jie, Munro James B, Blanchard Scott C, Frank Joachim

Abstract excerpt

mRNA-tRNA translocation is a central and highly regulated process during translational elongation. Along with the mRNA, tRNA moves through the ribosome in a stepwise fashion. Using cryoelectron microscopy on ribosomes with a P-loop mutation, we have identified novel structural intermediates likely to exist transiently during translocation. Our observations suggest a mechanism by which the rate of translocation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryoelectron Microscopy
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Peptide Chain Elongation, Translational

Share to Ribosomes

Share to RNA, Bacterial

Share to RNA, Messenger

Share to RNA, Transfer

Source

Open in PubMed Open full text

Identifiers

PMID: 21383139
DOI: 10.1073/pnas.1101503108
PMCID: PMC3064370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation.PMID 21383139Read ↗

Structured mRNAs regulate translation initiation by binding to the platform of the ribosome.Semantic proximity Read ↗

Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis.Semantic proximity Read ↗

Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.Semantic proximity Read ↗

Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosomeSemantic proximity Read ↗

Structure of the large ribosomal subunit from human mitochondria.Semantic proximity Read ↗

Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A.Semantic proximity Read ↗

Visualizing formation of the active site in the mitochondrial ribosome.Semantic proximity Read ↗

Structural adaptations for enhanced translation kinetics in evolved ribosomes.Semantic proximity Read ↗

Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human RibosomesSemantic proximity Read ↗

Structural and Functional Insights into Human Re-initiation Complexes.Semantic proximity Read ↗

Dissecting the molecular organization of the translocon-associated protein complex.Semantic proximity Read ↗

The hybrid state of tRNA binding is an authentic translation elongation intermediate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.