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Article

The hybrid state of tRNA binding is an authentic translation elongation intermediate.

Nature structural & molecular biology - 1 Mar 2006

Dorner Silke, Brunelle Julie L, Sharma Divya, Green Rachel

Abstract excerpt

The GTPase elongation factor (EF)-G is responsible for promoting the translocation of the messenger RNA-transfer RNA complex on the ribosome, thus opening up the A site for the next aminoacyl-tRNA. Chemical modification and cryo-EM studies have indicated that tRNAs can bind the ribosome in an alternative 'hybrid' state after peptidyl transfer and before translocation, though the relevance of this state during...

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Identifiers

PMID: 16501572
DOI: 10.1038/nsmb1060
PMCID: PMC1687179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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