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Article

A novel single amino acid change in small subunit ribosomal protein S5 has profound effects on translational fidelity.

RNA (New York, N.Y.) - 1 Dec 2006

Kirthi Narayanaswamy, Roy-Chaudhuri Biswajoy, Kelley Teresa, Culver Gloria M

Abstract excerpt

S5 is a small subunit ribosomal protein (r-protein) linked to the functional center of the 30S ribosomal subunit. In this study we have identified a unique amino acid mutation in Escherichia coli S5 that produces spectinomycin-resistance and cold sensitivity. This mutation significantly alters cell growth, folding of 16S ribosomal RNA, and translational fidelity. While translation initiation is not affected, both...

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Identifiers

PMID: 17053085
DOI: 10.1261/rna.302006
PMCID: PMC1664723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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