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Article

Kinetic properties of Escherichia coli ribosomes with altered forms of S12.

Journal of molecular biology - 20 Apr 1992

Bilgin N, Claesens F, Pahverk H, Ehrenberg M

Abstract excerpt

E. coli ribosomes with alterations in S12 leading to streptomycin resistance (SmR), dependence (SmD) and pseudodependence (SmP) were studied with the quench-flow technique. Kinetic changes at the various steps of the elongation cycle were identified. The rate of hydrolysis of GTP in the ternary complex in the ribosomal A-site is decreased drastically in SmD and moderately in SmP in relation to wild-type...

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PMID: 1569565
DOI: 10.1016/0022-2836(92)90466-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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