Kinetic properties of Escherichia coli ribosomes with altered forms of S12.

doi:10.1016/0022-2836(92)90466-w

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Article

Kinetic properties of Escherichia coli ribosomes with altered forms of S12.

Journal of molecular biology - 20 Apr 1992

Bilgin N, Claesens F, Pahverk H, Ehrenberg M

Abstract excerpt

E. coli ribosomes with alterations in S12 leading to streptomycin resistance (SmR), dependence (SmD) and pseudodependence (SmP) were studied with the quench-flow technique. Kinetic changes at the various steps of the elongation cycle were identified. The rate of hydrolysis of GTP in the ternary c...

Topics

Escherichia coli
GTP Phosphohydrolase-Linked Elongation Factors
Guanosine Triphosphate
Kinetics
Mutation
Peptide Chain Elongation, Translational
Peptide Elongation Factor Tu
Peptidyl Transferases
Ribosomal Proteins
Ribosomes
Streptomycin

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