Article
ATP binding to hemoglobin response gene 1 protein is necessary for regulation of the mating type locus in Candida albicans.
The Journal of biological chemistry - 22 Apr 2011
Peterson Alexander W, Pendrak Michael L, Roberts David D
Abstract excerpt
HBR1 (hemoglobin response gene 1) is an essential gene in Candida albicans that positively regulates mating type locus MTLα gene expression and thereby regulates cell type-specific developmental genes. Hbr1p contains a phosphate-binding loop (P-loop), a highly conserved motif characteristic of ATP- and GTP-binding proteins. Recombinant Hbr1p was isolated in an oligomeric state that specifically bound ATP with...
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