Article
Hemoglobin regulates expression of an activator of mating-type locus alpha genes in Candida albicans.
Eukaryotic cell - 1 Jun 2004
Pendrak Michael L, Yan S Steve, Roberts David D
Abstract excerpt
Phenotypic switching from the white to the opaque phase is a necessary step for mating in the pathogenic fungus Candida albicans. Suppressing switching during vascular dissemination of the organism may be advantageous, because opaque cells are more susceptible to host defenses. A repressor of white-opaque switching, HBR1 (hemoglobin response gene 1), was identified based on its specific induction following growth...
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