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Article

Functional analysis of heme regulatory elements of the transcriptional activator Hap1.

Biochemical and biophysical research communications - 5 Jul 2000

Hon T, Hach A, Lee H C, Cheng T, Zhang L

Abstract excerpt

Heme regulation of the activity of diverse proteins was thought to be mediated by heme-responsive motifs (HRMs). The yeast transcriptional activator Hap1 contains seven HRMs: HRM1-7. Three copies of a 17-amino-acid repeat are also located in the region encompassing HRM1 to -6. We examined the effects of these HRMs and repeats on heme regulation of Hap1 activity by deletion analysis and by Ala substitutions of key...

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Identifiers

PMID: 10873649
DOI: 10.1006/bbrc.2000.2995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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