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Article

Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype.

Neurotoxicology - 1 Oct 2002

Thiruchelvam Mona, Richfield Eric K, Goodman Becky M, Baggs Raymond B, Cory-Slechta Deborah A

Abstract excerpt

Idiopathic Parkinson's disease (PD) is associated with advanced age, but it is still unclear whether dopaminergic neuronal death results from events initiated during development, adulthood, or represents a cumulative effect across the span of life. This study hypothesized that paraquat (PQ) and maneb (MB) exposure during critical periods of development could permanently change the nigrostriatal dopamine (DA)...

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PMID: 12428734
DOI: 10.1016/s0161-813x(02)00092-x

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