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Article

Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.

Neurobiology of aging - 1 Mar 2017

Richter Franziska, Gabby Lauryn, McDowell Kimberly A, Mulligan Caitlyn K, De La Rosa Krystal, Sioshansi Pedrom C, Mortazavi Farzad, Cely Ingrid, Ackerson Larry C, Tsan Linda, Murphy Niall P, Maidment Nigel T, Chesselet Marie-Françoise

Abstract excerpt

How genetic variations in the dopamine transporter (DAT) combined with exposure to environmental toxins modulate the risk of Parkinson's disease remains unclear. Using unbiased stereology in DAT knock-down mice (DAT-KD) and wild-type (WT) littermates, we found that decreased DAT caused a loss of tyrosine hydroxylase-positive (dopaminergic) neurons in subregions of the substantia nigra pars compacta at 3-4 days,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28038352
DOI: 10.1016/j.neurobiolaging.2016.11.015
PMCID: PMC5292275

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