Article
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53.
Cell death & disease - 16 Dec 2010
Gonzalez-Cano L, Herreros-Villanueva M, Fernandez-Alonso R, Ayuso-Sacido A, Meyer G, Garcia-Verdugo J M, Silva A, Marques M M, Marin M C
Abstract excerpt
The question of how neural progenitor cells maintain its self-renewal throughout life is a fundamental problem in cell biology with implications in cancer, aging and neurodegenerative diseases. In this work, we have analyzed the p73 function in embryonic neural progenitor cell biology using the neurosphere (NS)-assay and showed that p73-loss has a significant role in the maintenance of neurosphere-forming cells...
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