Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NPC1 Gene Deficiency Leads to Lack of Neural Stem Cell Self-Renewal and Abnormal Differentiation Through Activation of p38 Mitogen-Activated Protein Kinase Signaling

11 Aug 2005

Abstract excerpt

Neural stem cells (NSCs) are capable of giving rise to neurons, glia, and astrocytes. Although self-renewal and differentiation in NSCs are regulated by many genes, such as Notch and Numb, little is known about the role of defective genes on the self-renewal and differentiation of NSCs from developing brain. The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative disease caused by a mutation of the NPC1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lysosomal Storage Disorders Research
Share to Moyamoya disease diagnosis and treatment
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16099992
DOI: 10.1634/stemcells.2005-0221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NPC1 Gene Deficiency Leads to Lack of Neural Stem Cell Self-Renewal and Abnormal Differentiation Through Activation of p38 Mitogen-Activated Protein Kinase SignalingPMID 16099992Read ↗

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.Semantic proximity Read ↗

Lovastatin promotes myelin formation in NPC1 mutant oligodendrocytes.Semantic proximity Read ↗

Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.Semantic proximity Read ↗

Neural Stem Cells, Neural Progenitors, and Neurotrophic FactorsSemantic proximity Read ↗

Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder.Semantic proximity Read ↗

Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells.Semantic proximity Read ↗

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway.Semantic proximity Read ↗

Menstrual blood-derived endometrial stem cells ameliorate neuroinflammation and apoptosis through JAK2/STAT3 signaling pathway in NPC1 mutant cell and miceSemantic proximity Read ↗

Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.Semantic proximity Read ↗

Evidence for a Niemann–Pick C (NPC) Gene Family: Identification and Characterization of NPC1L1Semantic proximity Read ↗

Neurofibromin Regulates Neural Stem Cell Proliferation, Survival, and Astroglial Differentiation In Vitro and In VivoSemantic proximity Read ↗

PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.