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Article

Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.

eLife - 7 May 2014

Mich John K, Signer Robert Aj, Nakada Daisuke, Pineda André, Burgess Rebecca J, Vue Tou Yia, Johnson Jane E, Morrison Sean J

Abstract excerpt

Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast(mid)EGFR(high)PlexinB2(high)CD24(-/low)O4/PSA-NCAM(-/low)Ter119/CD45(-) (GEPCOT) cells. They were highly...

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Identifiers

PMID: 24843006
DOI: 10.7554/eLife.02669
PMCID: PMC4038845

Genes

EGFR
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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