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Article

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

22 Sept 2014

Abstract excerpt

How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs rarely proliferate compared with their perinatal counterparts. Whether these relatively quiescent cells have the...

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PMID: 25246577
DOI: 10.1073/pnas.1414389111

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