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Article

TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.

Current biology : CB - 23 Nov 2010

Fujitani Masashi, Cancino Gonzalo I, Dugani Chandrasagar B, Weaver Ian C G, Gauthier-Fisher Andrée, Paquin Annie, Mak Tak W, Wojtowicz Martin J, Miller Freda D, Kaplan David R

Abstract excerpt

Increasing evidence suggests that deficits in adult stem cell maintenance cause aberrant tissue repair and premature aging [1]. While the mechanisms regulating stem cell longevity are largely unknown, recent studies have implicated p53 and its family member p63. Both proteins regulate organismal aging [2-4] as well as survival and self-renewal of tissue stem cells [5-9]. Intriguingly, haploinsufficiency for a...

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PMID: 21074438
DOI: 10.1016/j.cub.2010.10.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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