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Article

Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism.

Endocrine - 1 May 2024

Penna Gustavo C, Salas-Lucia Federico, Ribeiro Miriam O, Bianco Antonio C

Abstract excerpt

INTRODUCTION: Mutations and single nucleotide polymorphisms (SNPs) in the genes encoding the network of proteins involved in thyroid hormone signaling (TH) may have implications for the effectiveness of the treatment of hypothyroidism with LT4. It is conceivable that loss-of-function mutations or SNPs impair the ability of LT4 to be activated to T3, reach its targets, and ultimately resolve symptoms of...

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Identifiers

PMID: 37740833
DOI: 10.1007/s12020-023-03528-y
PMCID: PMC10959761

Genes

TH
DIO2

Variants

Provenance

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